
Mucinex 12HR Cold & Fever Multi-Symptom Extended- Release Tablet - 50 ct
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- NEW MUCINEX 12 HOUR COLD & FEVER MULTI-SYMPTOM TABLETS: Introducing the first and only over-the-counter 12 hour cold and flu medicine for adults that reduces fever and relieves cough, chest congestion, and body pain
- ALL DAY OR NIGHT MULTI-SYMPTOM RELIEF: One dose lasts 3x longer than most cold & flu medicines (compared to 1 dose of 4-hour medicine without re-dosing)
- FEVER REDUCTION & HEADACHE RELIEF: Contains Naproxen Sodium which reduces fever and relieves headache & minor pains
- COUGH SUPPRESSANT: Contains Dextromethorphan HBr which helps control cough
- EXCESS MUCUS RELIEF: Contains Guaifenesin which thins & loosens mucus and relieves chest congestion
- POWERFUL OVER-THE-COUNTER MEDICATION: Just 1 dose (2 tablets) in the morning and 1 dose (2 tablets) at night relieves symptoms for a full 24 hours, so you can say goodbye to re-dosing every 4 hours
- INNOVATIVE MUCINEX TECHNOLOGY: Bi-layer tablet with immediate and extended-release technology controls your symptoms all day or night
- TRUSTED BRAND: Mucinex is the #1 most trusted among physicians for cough & cold symptoms (IQVIA, ProVoice Survey, March 2026)
Mucinex 12HR Cold & Fever Multi-Symptom provides 12 hours of powerful multi-symptom relief from fever, headache, body pain, cough and chest congestion. Mucinex 12HR Cold & Fever Multi-Symptom Extended-Release Tablets contain an immediate-release layer on one side and an extended-release layer on the other side.
Feature Benefits:
- Mucinex 12HR Cold & Fever Multi-Symptom: Reduces fever, and relieves headache, body pains, cough and chest congestion
- Contains Naproxen Sodium which reduces fever and relieves headache & minor pains
- Contains Dextromethorphan HBr that helps control cough
- Contains Guaifenesin which thins and loosens mucus, and relieves chest congestion
- Bilayer tablet with extended-release technology
- 12-hour dosing
Relieves the following symptoms:
Reduces FeverBody Pain & HeadacheCoughChest CongestionProduct Highlights:
12 Hour DosingIntroducing Mucinex 12 Hour Cold & Fever Multi-Symptom Bi-Layer Tablets: The first and only over-the-counter cold and flu medicine that provides 12 hours of powerful multi-symptom relief from fever, headache, body pain, cough, and chest congestion. Thanks to our unique bi-layer tablet technology with an immediate-release layer and an extended-release layer, one dose lasts 3x longer than most cold and flu medicines.* Starts to release medicine immediately, while the extended-release layer keeps working for 12 hours.
Our one-of-a-kind formula contains powerful active ingredients that provide all day control of your worst cold and flu symptoms:
- Naproxen Sodium reduces fever and helps relieve headache and minor pains.
- Dextromethorphan HBr is a cough suppressant that helps control cough.
- Guaifenesin is an expectorant that thins & loosens mucus and relieves chest congestion.
Say goodbye to re-dosing every 4 hours: just 1 dose (2 tablets) in the morning and 1 dose (2 tablets) at night keeps you covered for a full 24 hours.
*compared to 1 dose of 4-hour medicine without re-dosing.In each tablet:
Dextromethorphan HBr (30 mg)
Guaifenesin (600 mg)
Naproxen sodium 110 mg (naproxen 100 mg) (NSAID*)
*nonsteroidal anti-inflammatory drug- Do not crush, chew, or break extended-release tablet.
- Do not take more than directed.
- Take each dose with a full glass of water.
- Adults and children 12 years and older: take 2 extended-release tablets every 12 hours; not more than 4 extended-release tablets in 24 hours.
- Children under 12 years of age: do not use.

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